Non-contact full-field optical coherence tomography: a novel tool for in vivo imaging of the human cornea (Conference Presentation)

Viacheslav Mazlin; Eugénie Dalimier; Katharine F. Grieve; Kristina Irsch; José-Alain Sahel; Mathias Fink; A. Claude Boccara

doi:10.1117/12.2251343

16 May 2017 Non-contact full-field optical coherence tomography: a novel tool for in vivo imaging of the human cornea (Conference Presentation)

Viacheslav Mazlin, Eugénie Dalimier, Katharine F. Grieve, Kristina Irsch, José-Alain Sahel, Mathias Fink, A. Claude Boccara

Author Affiliations +

Proceedings Volume 10045, Ophthalmic Technologies XXVII; 1004519 (2017) https://doi.org/10.1117/12.2251343
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

According to the World Health Organization (WHO), corneal diseases alongside with cataract and retinal diseases are major causes of blindness worldwide. For the 95.5% of corneal blindness cases, prevention or rehabilitation could have been possible without negative consequences for vision, provided that disease is diagnosed early. However, diagnostics at the early stage requires cellular-level resolution, which is not achieved with routinely used Slit-lamp and OCT instruments. Confocal microscopy allows examination of the cornea at a resolution approaching histological detail, however requires contact with a patient’s eye. The recently developed full-field OCT technique, in which 2D en face tangential optical slices are directly recorded on a camera, was successfully applied for ex vivo eye imaging. However, in vivo human eye imaging has not been demonstrated yet. Here we present a novel non-contact full-field OCT system, which is capable of imaging in air and, therefore, shows potential for in vivo cornea imaging in patients. The first cellular-level resolution ex vivo images of cornea, obtained in a completely non-contact way, were demonstrated. We were able to scan through the entire cornea (400 µm) and resolve epithelium, Bowman’s layer, stroma and endothelium. FFOCT images of the human cornea in vivo were obtained for the first time. The epithelium structures and stromal keratocyte cells were distinguishable. Both ex vivo and in vivo images were acquired with a large (1.26 mm x 1.26 mm) field of view. Cellular details in obtained images make this device a promising candidate for realization of high-resolution in vivo cornea imaging.

Conference Presentation

Citation Download Citation

Viacheslav Mazlin, Eugénie Dalimier, Katharine F. Grieve, Kristina Irsch, José-Alain Sahel, Mathias Fink, and A. Claude Boccara "Non-contact full-field optical coherence tomography: a novel tool for in vivo imaging of the human cornea (Conference Presentation)", Proc. SPIE 10045, Ophthalmic Technologies XXVII, 1004519 (16 May 2017); https://doi.org/10.1117/12.2251343

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

In vivo imaging

Cornea

Optical coherence tomography

Eye

Imaging systems

Cameras

Confocal microscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years