You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither SPIE nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the SPIE website.
8 February 2017Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging
Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) enable noninvasive in vivo diagnostic
imaging and provide complementary en face and depth-resolved visualization of ophthalmic structures, respectively. We
previously demonstrated concurrent multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and
OCT (SS-SESLO-OCT) at 1060 nm using a swept-source and double clad fiber coupler. Here, we present system
enhancements and novel designs for a modular SS-SESLO-OCT scan-head that can be coupled to ophthalmic surgical
microscope-integrated and slit-lamp imaging optics. Multimodal SS-SESLO-OCT was demonstrated using a custom-built
swept-source OCT engine with a 200 kHz 1060 nm source that was optically buffered for concurrent SESLO and OCT
imaging at 100% duty cycle and 400 kHz sweep-rate. A shared optical relay and fast-axis galvanometer ensured inherent
co-registration between SESLO and OCT field-of-views and concurrent acquisition of an en face SESLO image with each
OCT cross-section. SESLO and OCT frames were acquired at 200 fps with 2560 x 2000 pix. (spectral x lateral). We show
in vivo human ophthalmic imaging data using surgical microscope-integrated and slit-lamp imaging relays to demonstrate
the utility of our SS-SESLO-OCT design. Our self-contained modular scan-head can be used for either intraoperative
guidance or clinical diagnostics and reduces the complexity, cost, and maintenance required for clinical translation of these
technologies. We believe concurrent multimodal SS-SESLO-OCT may benefit 1) intraoperative imaging by allowing for
real-time surgical feedback, instrument tracking, and overlays of computationally extracted image-based surrogate
biomarkers of disease, and 2) slit-lamp imaging by enabling aiming, image registration, and multi-field mosaicking.
The alert did not successfully save. Please try again later.
Joseph D. Malone, Jianwei D. Li, Mohamed T. El-Haddad, Karen M. Joos M.D., Shriji N. Patel, Yuankai K. Tao, "Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging," Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100451D (8 February 2017); https://doi.org/10.1117/12.2252315