Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging

Joseph D. Malone; Jianwei D. Li; Mohamed T. El-Haddad; Karen M. Joos M.D.; Shriji N. Patel; Yuankai K. Tao

doi:10.1117/12.2252315

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8 February 2017 Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging

Joseph D. Malone, Jianwei D. Li, Mohamed T. El-Haddad, Karen M. Joos M.D., Shriji N. Patel, Yuankai K. Tao

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Proceedings Volume 10045, Ophthalmic Technologies XXVII; 100451D (2017) https://doi.org/10.1117/12.2252315
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) enable noninvasive in vivo diagnostic imaging and provide complementary en face and depth-resolved visualization of ophthalmic structures, respectively. We previously demonstrated concurrent multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) at 1060 nm using a swept-source and double clad fiber coupler. Here, we present system enhancements and novel designs for a modular SS-SESLO-OCT scan-head that can be coupled to ophthalmic surgical microscope-integrated and slit-lamp imaging optics. Multimodal SS-SESLO-OCT was demonstrated using a custom-built swept-source OCT engine with a 200 kHz 1060 nm source that was optically buffered for concurrent SESLO and OCT imaging at 100% duty cycle and 400 kHz sweep-rate. A shared optical relay and fast-axis galvanometer ensured inherent co-registration between SESLO and OCT field-of-views and concurrent acquisition of an en face SESLO image with each OCT cross-section. SESLO and OCT frames were acquired at 200 fps with 2560 x 2000 pix. (spectral x lateral). We show in vivo human ophthalmic imaging data using surgical microscope-integrated and slit-lamp imaging relays to demonstrate the utility of our SS-SESLO-OCT design. Our self-contained modular scan-head can be used for either intraoperative guidance or clinical diagnostics and reduces the complexity, cost, and maintenance required for clinical translation of these technologies. We believe concurrent multimodal SS-SESLO-OCT may benefit 1) intraoperative imaging by allowing for real-time surgical feedback, instrument tracking, and overlays of computationally extracted image-based surrogate biomarkers of disease, and 2) slit-lamp imaging by enabling aiming, image registration, and multi-field mosaicking.

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Joseph D. Malone, Jianwei D. Li, Mohamed T. El-Haddad, Karen M. Joos M.D., Shriji N. Patel, and Yuankai K. Tao "Modular multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography scan-head for surgical microscope-integrated and slit-lamp imaging", Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100451D (8 February 2017); https://doi.org/10.1117/12.2252315

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