8 February 2017 The relationship between 3D morphology of optic disc and spatial patterns of visual field loss in glaucoma
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Proceedings Volume 10045, Ophthalmic Technologies XXVII; 100451W (2017) https://doi.org/10.1117/12.2249690
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
Purpose: Optic disc tilt defined over 3D optic disc morphology has been shown to be associated with the location of initial glaucomatous damages. In this work, we study the impact of optic cup depth (OCD) on spatial patterns of visual field loss in glaucoma. Methods: Pairs of reliable Cirrus OCT scans around optic disc and Humphrey visual fields of glaucoma patients without visually significant cataract and age-related macular degeneration were selected. The most recent visit of a randomly selected eye of each patient was chosen. The OCD was automatically calculated on the superior-inferior cross sectional image passing through the optic disc center. The correlations between the mean pattern deviation (PD) of each sector in glaucoma hemifield test (GHT) and Garway-Heath scheme and OCD were evaluated for all severities glaucoma and mild glaucoma (mean deviation ≥ -5 dB), respectively. Results: 424 eyes of 424 patients passed the data reliability criteria with 346 mild glaucoma patients. For all severities glaucoma, there was no significant correlation between the mean sector PD and OCD. For mild glaucoma, OCD was uniquely correlated to the mean PD of the inferior pericentral sector (r=-0.18, p=0.01) in GHT, which was independent of mean deviation and retinal nerve fiber layer thickness (p<0.001 for both). Conclusion: OCD was uniquely correlated to the vision loss of the inferior pericentral sector in GHT and Garway- Health scheme for mild glaucoma. Future advancement of OCT imaging techniques may provide better clinical diagnosis for early glaucoma by focusing on 3D morphological variation of the optic disc.
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Mengyu Wang, Hui Wang, Neda Baniasadi, Tobias Elze, "The relationship between 3D morphology of optic disc and spatial patterns of visual field loss in glaucoma", Proc. SPIE 10045, Ophthalmic Technologies XXVII, 100451W (8 February 2017); doi: 10.1117/12.2249690; https://doi.org/10.1117/12.2249690
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