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13 February 2017 Direct visualization of functional heterogeneity in hepatobiliary metabolism
Chih-Ju Lin, Feng-Chieh Li, Yu-Yang Lee, Te-Yu Tseng, Wei-Lian Chen, Vladimir Hovhannisyan, Ning Kang, Nicholas G. Horton, Shu-Jen Chiang, Chris Xu, Hsuan-Shu Lee M.D., Chen-Yuan Dong
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Proceedings Volume 10046, Visualizing and Quantifying Drug Distribution in Tissue; 100460C (2017) https://doi.org/10.1117/12.2254952
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
Hepatycotes in the liver may appear similar in morphology, however, heterogeneities may exist in cellular metabolism. In this study, in vivo imaging of 6-carboxfluorescein diacetate (6-CFDA) metabolism in the liver was studied. We used two-photon fluorescence microscopy and hepatic window to provide quantification in studying hepatocellular metabolism. This model not only provides a potential platform for future study in hepatic responses and regulations, but also contributes to the fine-tuning of organ-specific functions so as to open up a new era of exciting discoveries.
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Chih-Ju Lin, Feng-Chieh Li, Yu-Yang Lee, Te-Yu Tseng, Wei-Lian Chen, Vladimir Hovhannisyan, Ning Kang, Nicholas G. Horton, Shu-Jen Chiang, Chris Xu, Hsuan-Shu Lee M.D., and Chen-Yuan Dong "Direct visualization of functional heterogeneity in hepatobiliary metabolism", Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 100460C (13 February 2017); https://doi.org/10.1117/12.2254952
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KEYWORDS
Mode conditioning cables
Liver
Luminescence
Visualization
Blood
Image processing
In vivo imaging
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