13 February 2017 Direct visualization of functional heterogeneity in hepatobiliary metabolism
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Abstract
Hepatycotes in the liver may appear similar in morphology, however, heterogeneities may exist in cellular metabolism. In this study, in vivo imaging of 6-carboxfluorescein diacetate (6-CFDA) metabolism in the liver was studied. We used two-photon fluorescence microscopy and hepatic window to provide quantification in studying hepatocellular metabolism. This model not only provides a potential platform for future study in hepatic responses and regulations, but also contributes to the fine-tuning of organ-specific functions so as to open up a new era of exciting discoveries.
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Chih-Ju Lin, Feng-Chieh Li, Yu-Yang Lee, Te-Yu Tseng, Wei-Lian Chen, Vladimir Hovhannisyan, Ning Kang, Nicholas G. Horton, Shu-Jen Chiang, Hung-Ming Lin, Chris Xu, Hsuan-Shu Lee, Chen-Yuan Dong, "Direct visualization of functional heterogeneity in hepatobiliary metabolism", Proc. SPIE 10046, Visualizing and Quantifying Drug Distribution in Tissue, 100460C (13 February 2017); doi: 10.1117/12.2254952; https://doi.org/10.1117/12.2254952
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