21 February 2017 A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT
Author Affiliations +
Uniform delivery of light fluence is an important goal for photodynamic therapy. We present summary results for an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, 8 detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. A MATLAB-based GUI program is developed to display the light dose in real-time during PDT to guide the PDT treatment delivery to improve the uniformity of the light dose. A dualcorrection algorithm is used to improve the agreement between calculations and in-situ measurements. A comprehensive analysis of the distribution of light fluence during PDT is presented in both phantom conditions and in clinical cases.
Conference Presentation
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Timothy C. Zhu, Timothy C. Zhu, Michele M. Kim, Michele M. Kim, Yi-Hong Ong, Yi-Hong Ong, Rozhin Penjweini, Rozhin Penjweini, Andreea Dimofte, Andreea Dimofte, Jarod C. Finlay, Jarod C. Finlay, Carmen Rodriguez, Carmen Rodriguez, Keith A. Cengel, Keith A. Cengel, } "A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT", Proc. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, 1004709 (21 February 2017); doi: 10.1117/12.2253027; https://doi.org/10.1117/12.2253027


Real-time treatment feedback guidance of Pleural PDT
Proceedings of SPIE (March 12 2013)
A brief history of Thermosense
Proceedings of SPIE (May 13 2018)
A treatment planning system for pleural PDT
Proceedings of SPIE (March 02 2010)
A real-time treatment guidance system for pleural PDT
Proceedings of SPIE (March 09 2012)

Back to Top