In vivo full-field time-domain optical coherence tomography using a spatially coherent off-axis reference (Conference Presentation)

Helge M. Sudkamp D.D.S.; Peter Koch; Dierck Hillmann; Hendrik Spahr; Gesa L. Franke; Michael Münst; Fabian Mütel; Gereon M. Hüttmann

doi:10.1117/12.2254850

19 April 2017 In vivo full-field time-domain optical coherence tomography using a spatially coherent off-axis reference (Conference Presentation)

Helge M. Sudkamp D.D.S., Peter Koch, Dierck Hillmann, Hendrik Spahr, Gesa L. Franke, Michael Münst, Fabian Mütel, Gereon M. Hüttmann

Author Affiliations +

Proceedings Volume 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI; 100531Q (2017) https://doi.org/10.1117/12.2254850
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Time domain OCT measures the interference between sample and reference radiation as a function of the reference arm length. In full-field-OCT (FF-OCT) a camera is used instead of a scanned beam for a parallel detection of the interference pattern and thus acquiring a complete en face image. Because multiple images have to be acquired to resolve the phase ambiguity, this method is prone to motion artifacts. We present a novel motion-insensitive approach to FF-OCT. Spatially coherent illumination and an off-axis reference beam is used to introduce path-length differences between reference and sample light in neighboring pixels. This spatial carrier frequency replaces the temporal carrier frequency in scanned TD-OCT. The setup is based on a Mach-Zehnder interferometer with a super-luminescent diode and a CMOS area camera. The Sensitivity of the system was determined to be 75 dB. The field of view was 1.42 x 1.42 mm. Each frame had 237x237 lateral channels at an axial resolution of 9 µm in tissue. By step-wise changing the length of the reference arm between the en face scans, volumetric in vivo FF-OCT measurements of the human retina have been acquired within 1.3 s. OCT with a spatially coherent off-axis reference beam is suitable for in vivo imaging of human retina. The quality of the images is sufficient to discriminate the different tissue layers.

Conference Presentation

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Helge M. Sudkamp D.D.S., Peter Koch, Dierck Hillmann, Hendrik Spahr, Gesa L. Franke, Michael Münst, Fabian Mütel, and Gereon M. Hüttmann "In vivo full-field time-domain optical coherence tomography using a spatially coherent off-axis reference (Conference Presentation)", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100531Q (19 April 2017); https://doi.org/10.1117/12.2254850

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KEYWORDS

Optical coherence tomography

In vivo imaging

Cameras

Retina

Tissues

CMOS cameras

Diodes

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