17 February 2017 Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves
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Shear wave OCE (SW-OCE) uses an OCT system to track propagating mechanical waves, providing the information needed to map the elasticity of the target sample. In this study we demonstrate high speed, 4D imaging to capture transient mechanical wave propagation. Using a high-speed Fourier domain mode-locked (FDML) swept-source OCT (SS-OCT) system operating at ~1.62 MHz A-line rate, the equivalent volume rate of mechanical wave imaging is 16 kvps (kilo-volumes per second), and total imaging time for a 6 x 6 x 3 mm volume is only 0.32 s. With a displacement sensitivity of ~10 nanometers, the proposed 4D imaging technique provides sufficient temporal and spatial resolution for real-time optical coherence elastography (OCE). Combined with a new air-coupled, high-frequency focused ultrasound stimulator requiring no contact or coupling media, this near real-time system can provide quantitative information on localized viscoelastic properties. SW-OCE measurements are demonstrated on tissue-mimicking phantoms and porcine cornea under various intra-ocular pressures. In addition, elasticity anisotropy in the cornea is observed. Images of the mechanical wave group velocity, which correlates with tissue elasticity, show velocities ranging from 4-20 m/s depending on pressure and propagation direction. These initial results strong suggest that 4D imaging for real-time OCE may enable high-resolution quantitative mapping of tissue biomechanical properties in clinical applications.
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Shaozhen Song, Shaozhen Song, Soon Joon Yoon, Soon Joon Yoon, Łukasz Ambroziński, Łukasz Ambroziński, Ivan Pelivanov, Ivan Pelivanov, David Li, David Li, Liang Gao, Liang Gao, Tueng T. Shen, Tueng T. Shen, Matthew O'Donnell, Matthew O'Donnell, Ruikang K. Wang, Ruikang K. Wang, } "Non-contact rapid optical coherence elastography by high-speed 4D imaging of elastic waves", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100531Y (17 February 2017); doi: 10.1117/12.2252980; https://doi.org/10.1117/12.2252980

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