17 February 2017 Speckle variance full-field optical coherence microscopy for high-resolution microvasculature mapping
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Abstract
This work reports on the feasibility of dynamic imaging using conventional reflectivity-based tomographic images obtained with full-field optical coherence microscopy (FF-OCM). Implementation of speckle variance for flow mapping with an imaging rate of 180 Hz is demonstrated by mapping 20% intralipid flowing into 100-μm-diameter microcapillary tubes at speeds up to ~ 50 mm/s. This constitutes a significant advance in high-resolution, real-time microvasculature mapping, using FF-OCM. The acquisition scheme in FF-OCM is particularly appropriate for en face visualization of the microvasculature, as FF-OCM directly acquires en face tomographic images unlike conventional OCT which usually requires reslicing of a three-dimensional data set to get en face images.
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Jonas Ogien, Jonas Ogien, Arnaud Dubois, Arnaud Dubois, } "Speckle variance full-field optical coherence microscopy for high-resolution microvasculature mapping", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100532O (17 February 2017); doi: 10.1117/12.2254836; https://doi.org/10.1117/12.2254836
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