17 February 2017 Tissue dispersion measurement techniques using optical coherence tomography
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Dispersion, a result of wavelength-dependent index of refraction variations, causes pulse-width broadening with detrimental effects in many pulsed-laser applications. It is also considered to be one of the major causes of resolution degradation in Optical Coherence Tomography (OCT). However, dispersion is material dependent and, in tissue, Group Velocity Dispersion (GVD) could be used, for example, to detect changes associated with early cancer and result in more accurate disease diagnosis. In this summary we compare different techniques for estimating the GVD from OCT images, in order to evaluate their accuracy and applicability in highly scattering samples such as muscle and adipose tissue. The methods investigated included estimation of the GVD from (i) the point spread function (PSF) degradation, (ii) the shift (walk-off) between images taken at different center wavelengths and (iii) the second derivative of the spectral phase. The measurements were degraded by the presence of strong Mie scattering and speckle noise with the most robust being the PSF degradation and the least robust the phase derivative method. If the GVD is to be used to provide sensitive diagnostic information from highly scattering human tissues, it would be preferable to use the resolution degradation as an estimator of GVD.
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Christos Photiou, Christos Photiou, Costas Pitris, Costas Pitris, } "Tissue dispersion measurement techniques using optical coherence tomography", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100532W (17 February 2017); doi: 10.1117/12.2251681; https://doi.org/10.1117/12.2251681

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