17 February 2017 Coagulation monitoring based on blood elastic measurement using optical coherence tomography
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Abstract
Blood coagulation monitoring is important to diagnose hematological diseases and cardiovascular diseases and to predict the risk of bleeding and excessive clotting. In this study, we developed a system to dynamically monitor blood coagulation and quantitatively determine the coagulation function by blood elastic measurement. When blood forms a clot from a liquid, ultrasonic force induces a shear wave, which is detected by optical coherence tomography (OCT). The coagulation of porcine whole blood recalcified by calcium chloride is assessed using the metrics of reaction time, clot formation kinetics and maximum shear modulus. The OCE system can noninvasively monitor the blood coagulation and quantitatively determine the coagulation function.
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Xiangqun Xu, Jiang Zhu, Zhongping Chen, "Coagulation monitoring based on blood elastic measurement using optical coherence tomography", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 1005332 (17 February 2017); doi: 10.1117/12.2248450; https://doi.org/10.1117/12.2248450
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