Evaluation and diagnosis of brain death by functional near-infrared spectroscopy

Boan Pan; Fulin Zhong; Xiaobo Huang; Lingai Pan; Sen Lu; Ting Li

doi:10.1117/12.2252142

14 February 2017 Evaluation and diagnosis of brain death by functional near-infrared spectroscopy

Boan Pan, Fulin Zhong, Xiaobo Huang, Lingai Pan, Sen Lu, Ting Li

Proceedings Volume 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV; 100541B (2017) https://doi.org/10.1117/12.2252142
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Brain death, the irreversible and permanent loss of the brain and brainstem functions, is hard to be judged precisely for some clinical reasons. The traditional diagnostic methods are time consuming, expensive and some are even dangerous. Functional near infrared spectroscopy (FNIRS), using the good scattering properties of major component of blood to NIR, is capable of noninvasive monitoring cerebral hemodynamic responses. Here, we attempt to use portable FNIRS under patients’ natural state for brain death diagnosis. Ten brain death patients and seven normal subjects participated in FNIRS measurements. All of them were provided different fractional concentration of inspired oxygen (FIO₂) in different time periods. We found that the concentration variation of deoxyhemoglobin concentration (Δ[Hb]) presents the trend of decrease in the both brain death patients and normal subjects with the raise of the FIO₂, however, the data in the normal subjects is more significant. And the concentration variation of oxyhemoglobins concentration (Δ[HbO₂]) emerges the opposite trends. Thus Δ[HbO₂]/Δ[Hb] in brain death patients is significantly higher than normal subjects, and emerges the rising trend as time went on. The findings indicated the potential of FNIRS-measured hemodynamic index in diagnosing brain death.

Citation Download Citation

Boan Pan, Fulin Zhong, Xiaobo Huang, Lingai Pan, Sen Lu, and Ting Li "Evaluation and diagnosis of brain death by functional near-infrared spectroscopy", Proc. SPIE 10054, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV, 100541B (14 February 2017); https://doi.org/10.1117/12.2252142

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available