Quartz-enhanced photo-acoustic spectroscopy for breath analyses

Jan C. Petersen; Laurent Lamard; Yuyang Feng; Jeff-F. Focant; Andre Peremans; Mikael Lassen

doi:10.1117/12.2252896

3 March 2017 Quartz-enhanced photo-acoustic spectroscopy for breath analyses

Jan C. Petersen, Laurent Lamard, Yuyang Feng, Jeff-F. Focant, Andre Peremans, Mikael Lassen

Proceedings Volume 10055, Optics and Biophotonics in Low-Resource Settings III; 1005503 (2017) https://doi.org/10.1117/12.2252896
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

An innovative and novel quartz-enhanced photoacoustic spectroscopy (QEPAS) sensor for highly sensitive and selective breath gas analysis is introduced. The QEPAS sensor consists of two acoustically coupled micro- resonators (mR) with an off-axis 20 kHz quartz tuning fork (QTF). The complete acoustically coupled mR system is optimized based on finite element simulations and experimentally verified. Due to the very low fabrication costs the QEPAS sensor presents a clear breakthrough in the field of photoacoustic spectroscopy by introducing novel disposable gas chambers in order to avoid cleaning after each test. The QEPAS sensor is pumped resonantly by a nanosecond pulsed single-mode mid-infrared optical parametric oscillator (MIR OPO). Spectroscopic measurements of methane and methanol in the 3.1 μm to 3.7 μm wavelength region is conducted. Demonstrating a resolution bandwidth of 1 cm^-1. An Allan deviation analysis shows that the detection limit at optimum integration time for the QEPAS sensor is 32 ppbv@190s for methane and that the background noise is solely due to the thermal noise of the QTF. Spectra of both individual molecules as well as mixtures of molecules were measured and analyzed. The molecules are representative of exhaled breath gasses that are bio-markers for medical diagnostics.

Conference Presentation

Citation Download Citation

Jan C. Petersen, Laurent Lamard, Yuyang Feng, Jeff-F. Focant, Andre Peremans, and Mikael Lassen "Quartz-enhanced photo-acoustic spectroscopy for breath analyses", Proc. SPIE 10055, Optics and Biophotonics in Low-Resource Settings III, 1005503 (3 March 2017); https://doi.org/10.1117/12.2252896

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available