15 March 2017 Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards
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Abstract
We report on a procedure to build and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Controlled inclusion of light scattering titanium dioxide (TiO2) nanoparticles enables the creation of phantoms having tunable light scattering properties with reduced scattering coefficients consistent across different measurement platforms including an integrating sphere and a time-resolved diffuse optical spectroscopic system. Backscatter confocal microscopy is also used to characterize the shape and distribution of included TiO2 particles. The double integrating sphere and time-resolved diffuse spectroscopy were used to measure the reduced scattering coefficients of the phantoms. The results across different systems are in good agreement, suggesting that the PDMS/TiO2 composite is a promising tissue-mimicking material for developing standards useful to validate measurements by different devices for multiplatform and multi-laboratory tests.
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Jeeseong Hwang, Hyun-Jin Kim, Paul Lemaillet, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, Thomas Gladytz, David McClatchy, David Allen, Kimberly Briggman, Brian Pogue, "Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards", Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 1005603 (15 March 2017); doi: 10.1117/12.2263379; https://doi.org/10.1117/12.2263379
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