14 March 2017 Multispectral fluorescence diffuse optical tomography
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Abstract
Fluorescence diffuse optical tomography (FDOT) has been widely used for in vivo small animal studies and the illposed problem in reconstruction can be eased by utilizing structural a priori obtained from an anatomic imaging modality. In this study, a multispectral fluorescence tomography (FT) is used, which has shown the ability to detect subtle shifts in the ICG absorption spectrum in our previous study. The imaging system is in trans-illumination mode with a swept-wavelength laser and a CCD on a rotation gantry and the structural image from the X-ray computed tomography is used to guide and constrain the FT reconstruction algorithm. In this work, a phantom with two inclusions filled with different fluorophores is utilized to evaluate whether the spectral information obtained using sweptwavelength laser can distinguish these two inclusions. The images are captured from 8 different views with three different wavelengths.
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Pei-An Lo, Pei-An Lo, Jaedu Cho, Jaedu Cho, Farouk Nouizi, Farouk Nouizi, Huihua Kenny Chiang, Huihua Kenny Chiang, Gultekin Gulsen, Gultekin Gulsen, } "Multispectral fluorescence diffuse optical tomography", Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560Z (14 March 2017); doi: 10.1117/12.2251363; https://doi.org/10.1117/12.2251363
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