24 March 2017 Simultaneous and co-localized acousto-optic measurements of spectral and temporal properties of diffusive media
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Abstract
Acousto-optic (AO) modulation of light is used to extract both temporal and spectral information of diffusive media such as biological tissue, where they provide measures of blood flow and oxygen saturation of hemoglobin, respectively. The temporal information is extracted from the width of the power spectrum of the light intensity, whereas the spectral information is calculated from the spatial decay of the cross correlation between the light intensity and the generated ultrasonic signal. The ultrasonic signal is a coded phase modulated signal with a narrow autocorrelation, enabling localization of the measurement volume. Two different liquid phantoms are used, with similar scattering but different absorption properties. The difference in absorption calculated with the AO signal is compared to calculations based on the modified Beer Lambert law. As the same AO signal is used to extract both modalities, it might be used to extract hemodynamic related changes in the brain for diagnostic and functional assessment.
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Michal Balberg, Michal Balberg, Revital Shechter, Revital Shechter, Pinhas Girshovitz, Pinhas Girshovitz, Ilan Breskin, Ilan Breskin, Sergio Fantini, Sergio Fantini, } "Simultaneous and co-localized acousto-optic measurements of spectral and temporal properties of diffusive media", Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 1005903 (24 March 2017); doi: 10.1117/12.2253848; https://doi.org/10.1117/12.2253848
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