17 February 2017 Real-time spatial frequency domain imaging by single snapshot multiple frequency demodulation technique
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Abstract
We have presented a novel Single Snapshot Multiple Frequency Demodulation (SSMD) method enabling single snapshot wide field imaging of optical properties of turbid media in the Spatial Frequency Domain. SSMD makes use of the orthogonality of harmonic functions and extracts the modulation transfer function (MTF) at multiple modulation frequencies and of arbitrary orientations and amplitudes simultaneously from a single structured-illuminated image at once. SSMD not only increases significantly the data acquisition speed and reduces motion artifacts but also exhibits excellent noise suppression in imaging as well. The performance of SSMD-SFDI is demonstrated with experiments on both tissue mimicking phantoms and in vivo for recovering optical properties. SSMD is ideal in the implementation of a real-time spatial frequency domain imaging platform, which will open up SFDI for vast applications in, for example, mapping the optical properties of a dynamic turbid medium or monitoring fast temporal evolutions.
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Zili Cao, Weihao Lin, Xinlin Chen, Bixin Zeng, Min Xu, "Real-time spatial frequency domain imaging by single snapshot multiple frequency demodulation technique", Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100590Z (17 February 2017); doi: 10.1117/12.2253992; https://doi.org/10.1117/12.2253992
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