17 February 2017 A fast atlas-guided high density diffuse optical tomography system for brain imaging
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Abstract
Near infrared spectroscopy (NIRS) is an emerging functional brain imaging tool capable of assessing cerebral concentrations of oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) during brain activation noninvasively. As an extension of NIRS, diffuse optical tomography (DOT) not only shares the merits of providing continuous readings of cerebral oxygenation, but also has the ability to provide spatial resolution in the millimeter scale. Based on the scattering and absorption properties of nonionizing near-infrared light in biological tissue, DOT has been successfully applied in the imaging of breast tumors, osteoarthritis and cortex activations. Here, we present a state-of-art fast high density DOT system suitable for brain imaging. It can achieve up to a 21 Hz sampling rate for a full set of two-wavelength data for 3-D DOT brain image reconstruction. The system was validated using tissue-mimicking brain-model phantom. Then, experiments on healthy subjects were conducted to demonstrate the capability of the system.
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Xianjin Dai, Xianjin Dai, Tao Zhang, Tao Zhang, Hao Yang, Hao Yang, Huabei Jiang, Huabei Jiang, } "A fast atlas-guided high density diffuse optical tomography system for brain imaging", Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100591I (17 February 2017); doi: 10.1117/12.2251534; https://doi.org/10.1117/12.2251534
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