18 February 2017 An endoscopic diffuse optical tomographic method with high resolution based on the improved FOCUSS method
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Endoscopic DOT has the potential to apply to cancer-related imaging in tubular organs. Although the DOT has relatively large tissue penetration depth, the endoscopic DOT is limited by the narrow space of the internal tubular tissue, so as to the relatively small penetration depth. Because some adenocarcinomas including cervical adenocarcinoma are located in deep canal, it is necessary to improve the imaging resolution under the limited measurement condition. To improve the resolution, a new FOCUSS algorithm along with the image reconstruction algorithm based on the effective detection range (EDR) is developed. This algorithm is based on the region of interest (ROI) to reduce the dimensions of the matrix. The shrinking method cuts down the computation burden. To reduce the computational complexity, double conjugate gradient method is used in the matrix inversion. For a typical inner size and optical properties of the cervix-like tubular tissue, reconstructed images from the simulation data demonstrate that the proposed method achieves equivalent image quality to that obtained from the method based on EDR when the target is close the inner boundary of the model, and with higher spatial resolution and quantitative ratio when the targets are far from the inner boundary of the model. The quantitative ratio of reconstructed absorption and reduced scattering coefficient can be up to 70% and 80% under 5mm depth, respectively. Furthermore, the two close targets with different depths can be separated from each other. The proposed method will be useful to the development of endoscopic DOT technologies in tubular organs.
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Zhuanping Qin, Zhuanping Qin, Wenjuan Ma, Wenjuan Ma, Shuyan Ren, Shuyan Ren, Liqing Geng, Liqing Geng, Jing Li, Jing Li, Ying Yang, Ying Yang, Yingmei Qin, Yingmei Qin, } "An endoscopic diffuse optical tomographic method with high resolution based on the improved FOCUSS method", Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 1005920 (18 February 2017); doi: 10.1117/12.2250296; https://doi.org/10.1117/12.2250296

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