Mapping of electrophysiological response to transcranial infrared laser stimulation on the human brain in vivo measured by electroencephalography (Conference Presentation)

Xinlong Wang; Divya Dhandapani Reddy; F. Gonzalez-Lima; Hanli Liu

doi:10.1117/12.2253485

19 April 2017 Mapping of electrophysiological response to transcranial infrared laser stimulation on the human brain in vivo measured by electroencephalography (Conference Presentation)

Xinlong Wang, Divya Dhandapani Reddy, F. Gonzalez-Lima, Hanli Liu

Author Affiliations +

Proceedings Volume 10062, Optical Interactions with Tissue and Cells XXVIII; 100620P (2017) https://doi.org/10.1117/12.2253485
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Transcranial infrared laser stimulation (TILS) is a non-destructive and non-thermal photobiomodulation therapy or process on the human brain; TILS uses infrared light from lasers or LEDs and has gained increased recognition for its beneficial effects on a variety of neurological and psychological conditions. While the mechanism of TILS has been assumed to stem from cytochrome-c-oxidase (CCO), which is the last enzyme in the electron transportation chain and is the primary photoacceptor, no literature is found to report electrophysiological response to TILS. In this study, a 64-channel electroencephalography (EEG) system was employed to monitor electrophysiological activities from 15 healthy human participants before, during and after TILS. A placebo experimental protocol was also applied for rigorous comparison. After recording a 3-minute baseline, we applied a 1064-nm laser with a power of 3.5W on the right forehead of each human participant for 8 minutes, followed by a 5-minute recovery period. In 64-channel EEG data analysis, we utilized several methods (root mean square, principal component analysis followed by independent component analysis, permutation conditional mutual information, and time-frequency wavelet analysis) to reveal differences in electrophysiological response to TILS between the stimulated versus placebo group. The analyzed results were further investigated using general linear model and paired t-test to reveal statistically meaningful responses induced by TILS. Moreover, this study will provide spatial mapping of human electrophysiological and possibly neural network responses to TILS for first time, indicating the potential of EEG to be an effective method for monitoring neurological improvement induced by TILS.

Conference Presentation

Citation Download Citation

Xinlong Wang, Divya Dhandapani Reddy, F. Gonzalez-Lima, and Hanli Liu "Mapping of electrophysiological response to transcranial infrared laser stimulation on the human brain in vivo measured by electroencephalography (Conference Presentation)", Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII, 100620P (19 April 2017); https://doi.org/10.1117/12.2253485

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KEYWORDS

Electroencephalography

Infrared lasers

Brain

Brain mapping

In vivo imaging

Laser therapeutics

Statistical analysis

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