In vivo monitoring laser tissue interaction using high resolution Fourier-domain optical coherence tomography

Hang Chan Jo; Dong Jun Shin; Jin-Chul Ahn; Phil-Sang Chung; DaeYu Kim

doi:10.1117/12.2251558

15 February 2017 In vivo monitoring laser tissue interaction using high resolution Fourier-domain optical coherence tomography

Hang Chan Jo, Dong Jun Shin, Jin-Chul Ahn, Phil-Sang Chung, DaeYu Kim

Author Affiliations +

Proceedings Volume 10062, Optical Interactions with Tissue and Cells XXVIII; 1006217 (2017) https://doi.org/10.1117/12.2251558
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Laser-induced therapies include laser ablation to remove or cut target tissue by irradiating high-power focused laser beam. These laser treatments are widely used tools for minimally invasive surgery and retinal surgical procedures in clinical settings. In this study, we demonstrate laser tissue interaction images of various sample tissues using high resolution Fourier-domain optical coherence tomography (Fd-OCT). We use a Q-switch diode-pumped Nd:YVO4 nanosecond laser (532nm central wavelength) with a 4W maximum output power at a 20 kHz repetition rate to ablate in vitro and in vivo samples including chicken breast and mouse ear tissues. The Fd-OCT system acquires time-series Bscan images at the same location during the tissue ablation experiments with 532nm laser irradiation. The real-time series of OCT cross-sectional (B-scan) images compare structural changes of 532nm laser ablation using same and different laser output powers. Laser tissue ablation is demonstrated by the width and the depth of the tissue ablation from the B-scan images.

Citation Download Citation

Hang Chan Jo, Dong Jun Shin, Jin-Chul Ahn, Phil-Sang Chung, and DaeYu Kim "In vivo monitoring laser tissue interaction using high resolution Fourier-domain optical coherence tomography", Proc. SPIE 10062, Optical Interactions with Tissue and Cells XXVIII, 1006217 (15 February 2017); https://doi.org/10.1117/12.2251558

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