Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.
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Teemu Myllylä, Erkki Vihriälä, Matteo Pedone, Vesa Korhonen, Lukasz Surazynski, Maciej Wróbel, Aleksandra Zienkiewicz, Jaakko Hakala, Hannu Sorvoja, Janne Lauri, Tapio Fabritius, Małgorzata Jędrzejewska-Szczerska, Vesa Kiviniemi, Igor Meglinski, "Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation," Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100630M (3 March 2017);