3 March 2017 Diagnostics of oral lichen planus based on analysis of volatile organic compounds in saliva
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Abstract
The ability of diagnostics of oral lichen planus (OLP) based on spectral analysis of saliva using the THz spectroscopy is presented. The study included 8 patients with clinically proven OLP. The comparison group consisted of 8 healthy volunteers. Absorption spectra of the saliva was measured using time-domain spectrometer T-spec (EXPLA) in the range 0.2-3THz and have been considered as the feature vectors of the state. The spatial distribution of the objects under study in the feature space was analyzed using principle component analysis. The groups under study were shown to separate in full. Thus, the saliva analysis by the THz spectroscopy technique can be potentially used as a method of noninvasive diagnostics of the OLP.
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Yury Kistenev, Yury Kistenev, Alexey Borisov, Alexey Borisov, Alexander Shapovalov, Alexander Shapovalov, Olga Baydik, Olga Baydik, Maria Titarenko, Maria Titarenko, } "Diagnostics of oral lichen planus based on analysis of volatile organic compounds in saliva", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100630R (3 March 2017); doi: 10.1117/12.2252131; https://doi.org/10.1117/12.2252131
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