3 March 2017 Continuous blood pressure recordings simultaneously with functional brain imaging: studies of the glymphatic system
Author Affiliations +
The lymph system is responsible for cleaning the tissues of metabolic waste products, soluble proteins and other harmful fluids etc. Lymph flow in the body is driven by body movements and muscle contractions. Moreover, it is indirectly dependent on the cardiovascular system, where the heart beat and blood pressure maintain force of pressure in lymphatic channels. Over the last few years, studies revealed that the brain contains the so-called glymphatic system, which is the counterpart of the systemic lymphatic system in the brain. Similarly, the flow in the glymphatic system is assumed to be mostly driven by physiological pulsations such as cardiovascular pulses. Thus, continuous measurement of blood pressure and heart function simultaneously with functional brain imaging is of great interest, particularly in studies of the glymphatic system.

We present our MRI compatible optics based sensing system for continuous blood pressure measurement and show our current results on the effects of blood pressure variations on cerebral brain dynamics, with a focus on the glymphatic system. Blood pressure was measured simultaneously with near-infrared spectroscopy (NIRS) combined with an ultrafast functional brain imaging (fMRI) sequence magnetic resonance encephalography (MREG, 3D brain 10 Hz sampling rate).
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Aleksandra Zienkiewicz, Aleksandra Zienkiewicz, Niko Huotari, Niko Huotari, Lauri Raitamaa, Lauri Raitamaa, Ville Raatikainen, Ville Raatikainen, Hany Ferdinando, Hany Ferdinando, Erkki Vihriälä, Erkki Vihriälä, Vesa Korhonen, Vesa Korhonen, Teemu Myllylä, Teemu Myllylä, Vesa Kiviniemi, Vesa Kiviniemi, } "Continuous blood pressure recordings simultaneously with functional brain imaging: studies of the glymphatic system", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 1006311 (3 March 2017); doi: 10.1117/12.2252032; https://doi.org/10.1117/12.2252032

Back to Top