3 March 2017 Common-path biodynamic imaging for dynamic fluctuation spectroscopy of 3D living tissue
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Abstract
Biodynamic imaging is a novel 3D optical imaging technology based on short-coherence digital holography that measures intracellular motions of cells inside their natural microenvironments. Here both common-path and Mach-Zehnder designs are presented. Biological tissues such as tumor spheroids and ex vivo biopsies are used as targets, and backscattered light is collected as signal. Drugs are applied to samples, and their effects are evaluated by identifying biomarkers that capture intracellular dynamics from the reconstructed holograms. Through digital holography and coherence gating, information from different depths of the samples can be extracted, enabling the deep-tissue measurement of the responses to drugs.
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Zhe Li, Zhe Li, John Turek, John Turek, David D. Nolte, David D. Nolte, } "Common-path biodynamic imaging for dynamic fluctuation spectroscopy of 3D living tissue", Proc. SPIE 10063, Dynamics and Fluctuations in Biomedical Photonics XIV, 100631G (3 March 2017); doi: 10.1117/12.2251439; https://doi.org/10.1117/12.2251439
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