3 March 2017 Deep-tissue photoacoustic imaging at 1064 nm using a contrast agent based on phosphorus phthalocyanine formulation
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Abstract
This study demonstrated the performance of photoacoustic imaging at 1064 nm using phosphorus phthalocyanine (P-Pc), a contrast agent with strong absorption at 1064 nm. Due to high maximum permissible exposure of 1064 nm laser light and strong absorbance of P-Pc at 1064 nm, we demonstrated an imaging depth of 11.6 cm in chicken breast tissue. For animal imaging, we used P-Pc to target tumor and to track intestine dynamics. Thus, using a contrast medium with extreme absorption at 1064 nm readily enables high quality photoacoustic imaging at exceptional depths.
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Depeng Wang, Depeng Wang, Yang Zhou, Yang Zhou, Yumiao Zhang, Yumiao Zhang, Jumin Geng, Jumin Geng, Yuehang Wang, Yuehang Wang, Yuzhen Zhang, Yuzhen Zhang, Timothy R. Cook, Timothy R. Cook, Jonathan F. Lovell, Jonathan F. Lovell, Jun Xia, Jun Xia, } "Deep-tissue photoacoustic imaging at 1064 nm using a contrast agent based on phosphorus phthalocyanine formulation", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100642X (3 March 2017); doi: 10.1117/12.2253320; https://doi.org/10.1117/12.2253320
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