3 March 2017 A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent
Author Affiliations +
Abstract
A PEGylated quinoline-annulated porphyrin derivative was synthesized as in vivo photoacoustic tomography contrast agent. It possesses high solubility and stability in water and phosphate-buffered saline. No toxicity sign was observed in BALB/c mice. The dye demonstrates a 4-fold higher photoacoustic signal generation efficiency compared to fresh rat blood. Injection of the dye results in a significant enhancement of in vivo PAT images of murine tumors. Analysis of the mouse urine after injection revealed an unaltered renal filtration of the contrast agent.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Mohsen Erfanzadeh, Mohsen Erfanzadeh, Michael Luciano, Michael Luciano, Feifei Zhou, Feifei Zhou, Christian Brückner, Christian Brückner, Quing Zhu, Quing Zhu, } "A monomeric water-soluble NIR-absorbing porphyrin derivative as in vivo photoacoustic tomography contrast agent", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006432 (3 March 2017); doi: 10.1117/12.2249877; https://doi.org/10.1117/12.2249877
PROCEEDINGS
7 PAGES


SHARE
Back to Top