3 March 2017 N-doped carbon nanodots for non-invasive photoacoustic imaging and photothermal therapy
Author Affiliations +
We synthesized nitrogen-doped carbon nanodots (N-CNDs) for photoacoustic (PA) imaging and photothermal therapy (PTT) by controlling the nitrogen source and carbonizing organic acids. The N-CNDs showed strong optical absorbance in the near-infrared region, with great photostability and biodegradability. Thanks to the strong optical absorbance of NCNDs, the PA signals from N-CNDs were high enough to detect inside living animals and enabled minimally invasive PTT using N-CND. To evaluate the biodegradability and potential application of N-CNDs as a PA imaging contrast agent, we performed time-resolved PA imaging of sentinel lymph nodes (SLNs) and assessed renal clearance after hypodermic injection. SLN and vascular networks were photoacoustically visualized by an acoustic-resolution reflection-mode PA imaging system at a 680-nm optical wavelength. Furthermore, we performed whole-body PA imaging after subcutaneous injection of N-CNDs to assess their body distribution and clearance. Finally, we further investigated the use of N-CNDs for in vivo photothermal therapy in Balb/c nude xenograft HepG2-tumor model mice.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Donghyun Lee, Donghyun Lee, Changho Lee, Changho Lee, Woosung Kwon, Woosung Kwon, Songeun Beack, Songeun Beack, Chulhong Kim, Chulhong Kim, } "N-doped carbon nanodots for non-invasive photoacoustic imaging and photothermal therapy", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006433 (3 March 2017); doi: 10.1117/12.2251137; https://doi.org/10.1117/12.2251137

Back to Top