3 March 2017 Detection of ICG at low concentrations by photoacoustic imaging system using LED light source
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Recently, various type of photoacoustic imaging (PAI) that can visualize properties and distribution of light absorber have been researched. We developed PAI system using LED light source and evaluated characteristics of photoacoustic signal intensity versus Indocyanine Green (ICG) concentration. In this experiment, a linear type PZT array transducer (128-elements, 10.0MHz center frequency) was used to be able to transmit and receive ultrasound and also detect photoacoustic signal from the target object. The transducer was connected to the PAI system, and two sets of LED light source that had 850nm wavelength chip array were set to the both side of the transducer. The transducer head was placed at a distance of 20 mm from the target in the water bath. The target object was a tube filled with ICG in it. The tubes containing ICG at concentrations from 300nanomolar to 3millimolar were made by diluting original ICG solution. We measured the photoacoustic signal strength from RF signal generated from the ICG in the tube, and the results showed that the intensity of the signal was almost linear response to the concentration in log-log scale.
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Yusuke Shigeta, Toshitaka Agano, Naoto Sato, Hitoshi Nakatsuka, Kazuo Kitagawa, Takamitsu Hanaoka, Koji Morisono, and Chizuyo Tanaka "Detection of ICG at low concentrations by photoacoustic imaging system using LED light source", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100644X (3 March 2017); doi: 10.1117/12.2251678; https://doi.org/10.1117/12.2251678

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