3 March 2017 Light activated microbubbles for imaging and microsurgery
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Imaging and microsurgery procedures based on the photoacoustic effect have recently attracted much attention for cancer treatment. Light absorption in the nanosecond regime triggers thermoelastic processes that induce ultrasound emission and even cavitation. The ultrasound waves may be detected to reconstruct images, while cavitation may be exploited to kill malignant cells. The potential of gold nanorods as contrast agents for photoacoustic imaging has been extensively investigated, but still little is known about their use to trigger cavitation. Here, we investigated the influence of environment thermal properties on the ability of gold nanorods to trigger cavitation by probing the photoacoustic emission as a function of the excitation fluence. We are confident that these results will provide useful directions to the development of new strategies for therapies based on the photoacoustic effect.
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Lucia Cavigli, Lucia Cavigli, Filippo Micheletti, Filippo Micheletti, Paolo Tortoli, Paolo Tortoli, Sonia Centi, Sonia Centi, Sarah Lai, Sarah Lai, Claudia Borri, Claudia Borri, Francesca Rossi, Francesca Rossi, Fulvio Ratto, Fulvio Ratto, Roberto Pini, Roberto Pini, } "Light activated microbubbles for imaging and microsurgery", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006457 (3 March 2017); doi: 10.1117/12.2252783; https://doi.org/10.1117/12.2252783

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