Structural and functional imaging for vascular targeted photodynamic therapy

Buhong Li; Ying Gu; Brian C. Wilson

doi:10.1117/12.2253802

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20 February 2017 Structural and functional imaging for vascular targeted photodynamic therapy

Buhong Li; Ying Gu; Brian C. Wilson

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Proceedings Volume 10065, Biophotonics and Immune Responses XII; 1006504 (2017) https://doi.org/10.1117/12.2253802
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Vascular targeted photodynamic therapy (V-PDT) has been widely used for the prevention or treatment of vascular-related diseases, such as localized prostate cancer, wet age-related macular degeneration, port wine stains, esophageal varices and bleeding gastrointestinal mucosal lesions. In this study, the fundamental mechanisms of vascular responses during and after V-PDT will be introduced. Based on the V-PDT treatment of blood vessels in dorsal skinfold window chamber model, the structural and functional imaging, which including white light microscopy, laser speckle imaging, singlet oxygen luminescence imaging, and fluorescence imaging for evaluating vascular damage will be presented, respectively. The results indicate that vessel constriction and blood flow dynamics could be considered as the crucial biomarkers for quantitative evaluation of vascular damage. In addition, future perspectives of non-invasive optical imaging for evaluating vascular damage of V-PDT will be discussed.

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Buhong Li, Ying Gu, and Brian C. Wilson "Structural and functional imaging for vascular targeted photodynamic therapy", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 1006504 (20 February 2017); https://doi.org/10.1117/12.2253802

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