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20 February 2017 Measurements of gold nanoparticle concentration with K-shell x-ray fluorescence spectrum
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Proceedings Volume 10065, Biophotonics and Immune Responses XII; 100650M (2017)
Event: SPIE BiOS, 2017, San Francisco, California, United States
In this study, the AuNP k-shell fluorescence spectra were measured by using a 100 mm long collimator to improve the detectability. The AuNPs were suspended in deionized water at different concentrations. The AuNP suspensions were excited by a micro focal spot x-ray tube with 130 kVp, 300 μA x-ray exposures. The emissions of the AuNP fluorescence were measured by a spectrometer located with an angle of 90 degrees with respect to the excitation beam. The fluorescence acquisition durations for each concentration mode were 3000 s. A 1.0 mm Pb filter and a 1 mm Al filter were utilized to optimize excitation beam and fluorescence emission, respectively. As a result, the k-shell fluorescence peaks, 66.99 keV and 68.80 keV of AuNP, were measured and observed in 0.1, 0.2, 0.4, 0.8, 1.0, 2.0, 4.0 mg/mL concentration modes. The linear relationship between the AuNP suspension concentrations and the number of photons of the fluorescence peaks were observed in the range of 0.1–4.0 mg/mL. The results of experimental measurements demonstrated up to 0.1 mg/mL (0.01 % in weight concentration) detectability.
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© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Di Wu, Molly D. Wong, Yuhua Li, Muhammad U. Ghani, Bin Zheng, Wei R. Chen, and Hong Liu "Measurements of gold nanoparticle concentration with K-shell x-ray fluorescence spectrum", Proc. SPIE 10065, Biophotonics and Immune Responses XII, 100650M (20 February 2017);


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