22 February 2017 A theranostic platform for localized magnetic fluid hyperthermia and magnetic particle imaging
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Abstract
Magnetic fluid hyperthermia (MFH) is a promising avenue for noninvasive or minimally invasive therapies including tissue ablation, hyperthermia, and drug delivery. Magnetic particle imaging (MPI) is a promising new medical imaging modality with wide-ranging applications including angiography, cell tracking, and cancer imaging. MFH and MPI are kindred technologies leveraging the same physics: Both MFH and MPI function by exciting iron oxide magnetic nanoparticles with AC magnetic fields. In this manuscript, we show that this can be leveraged for combined MPI-MFH. The gradient fields employed in MPI can benefit MFH by providing high resolution targeting anywhere in the body, and a dual system provides opportunities for real-time diagnostic imaging feedback. Here we experimentally quantify the spatial localization of MFH using MPI gradient fields with a custom MPI-MFH system, demonstrating approximately 3 mm heating resolution in phantoms. We show an ability to precisely target phantom components as desired and provide heating of approximately 150 W g-1. We also show preliminary simultaneous MPI-MFH data.
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Daniel Hensley, Daniel Hensley, Zhi Wei Tay, Zhi Wei Tay, Rohan Dhavalikar, Rohan Dhavalikar, Patrick Goodwill, Patrick Goodwill, Bo Zheng, Bo Zheng, Carlos Rinaldi, Carlos Rinaldi, Steven Conolly, Steven Conolly, } "A theranostic platform for localized magnetic fluid hyperthermia and magnetic particle imaging", Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 1006603 (22 February 2017); doi: 10.1117/12.2256350; https://doi.org/10.1117/12.2256350
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