22 February 2017 A theranostic platform for localized magnetic fluid hyperthermia and magnetic particle imaging
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Magnetic fluid hyperthermia (MFH) is a promising avenue for noninvasive or minimally invasive therapies including tissue ablation, hyperthermia, and drug delivery. Magnetic particle imaging (MPI) is a promising new medical imaging modality with wide-ranging applications including angiography, cell tracking, and cancer imaging. MFH and MPI are kindred technologies leveraging the same physics: Both MFH and MPI function by exciting iron oxide magnetic nanoparticles with AC magnetic fields. In this manuscript, we show that this can be leveraged for combined MPI-MFH. The gradient fields employed in MPI can benefit MFH by providing high resolution targeting anywhere in the body, and a dual system provides opportunities for real-time diagnostic imaging feedback. Here we experimentally quantify the spatial localization of MFH using MPI gradient fields with a custom MPI-MFH system, demonstrating approximately 3 mm heating resolution in phantoms. We show an ability to precisely target phantom components as desired and provide heating of approximately 150 W g-1. We also show preliminary simultaneous MPI-MFH data.
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Daniel Hensley, Zhi Wei Tay, Rohan Dhavalikar, Patrick Goodwill, Bo Zheng, Carlos Rinaldi, and Steven Conolly "A theranostic platform for localized magnetic fluid hyperthermia and magnetic particle imaging", Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 1006603 (22 February 2017); doi: 10.1117/12.2256350; https://doi.org/10.1117/12.2256350

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