Assessing the changes in the spatial stiffness of the posterior sclera as a function of IOP with air-pulse OCE

Manmohan Singh; Achuth Nair; Salavat R. Aglyamov; Chen Wu; Zhaolong Han; Ericka Lafon; Kirill V. Larin

doi:10.1117/12.2251550

21 February 2017 Assessing the changes in the spatial stiffness of the posterior sclera as a function of IOP with air-pulse OCE

Manmohan Singh, Achuth Nair, Salavat R. Aglyamov, Chen Wu, Zhaolong Han, Ericka Lafon, Kirill V. Larin

Author Affiliations +

Proceedings Volume 10067, Optical Elastography and Tissue Biomechanics IV; 100670F (2017) https://doi.org/10.1117/12.2251550
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The mechanophysiology of tissues in the posterior eye have been implicated for diseases such as myopia and glaucoma. For example, the eye-globe shape, and consequently optical axial length, can be affected by scleral stiffness. In glaucoma, an elevated intraocular pressure is the primary risk factor for glaucoma, which is the 2nd most prevalent known cause of blindness. Recent work has shown that biomechanical properties of the optic nerve are critical for the onset and progression of glaucoma because weak tissues cause large displacements in the optic nerve, causing tissue damage. In this work, we utilize air-pulse optical coherence elastography (OCE) to quantify the spatial distribution of biomechanical properties of the optic nerve, its surrounding tissues, and the posterior sclera. Air-pulse measurements were made in a grid on in situ porcine eyes in the whole eye-globe configuration as various IOPs. The OCE-measured displacement process was linked to tissue stiffness by a simple kinematic equation. The results show that the optic nerve and peripapillary sclera are much stiffer than the surrounding sclera, and the stiffness of the optic nerve and peripapillary sclera increased as a function of IOP. However, the stiffness of the surrounding sclera did not dramatically increase. Our results show that understanding the dynamics of the biomechanical properties of the eye are critical to understand the aforementioned diseases and may provide additional information for assessing visual health and integrity.

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Manmohan Singh, Achuth Nair, Salavat R. Aglyamov, Chen Wu, Zhaolong Han, Ericka Lafon, and Kirill V. Larin "Assessing the changes in the spatial stiffness of the posterior sclera as a function of IOP with air-pulse OCE", Proc. SPIE 10067, Optical Elastography and Tissue Biomechanics IV, 100670F (21 February 2017); https://doi.org/10.1117/12.2251550

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KEYWORDS

Tissues

Sclera

Optic nerve

Optical coherence tomography

Elastography

Eye

Tissue optics

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