21 February 2017 Optimal selection of laser modulation parameters in photothermal optical coherence tomography
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Abstract
Photothermal optical coherence tomography (PT-OCT) employs a secondary intensity-modulated photothermal laser to create modulated thermal strains that cause variations of the refractive index in the proximity of absorbing chromophores. These variations are directly detected with phase-sensitive OCT and offer insight to the molecular composition and thermo-elastic properties of the sample. Here, we define optimal PT laser modulation parameters by investigating the effect of PT laser power and modulation frequency on the ensuing thermal waves and thermal waves’ impact on the spatial resolution of PT-OCT imaging based on numerical simulations of PT-OCT and samples containing point absorbers.
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Ashish Gupta, Martin Villiger, Nima Tabatabaei, "Optimal selection of laser modulation parameters in photothermal optical coherence tomography", Proc. SPIE 10067, Optical Elastography and Tissue Biomechanics IV, 1006718 (21 February 2017); doi: 10.1117/12.2252779; https://doi.org/10.1117/12.2252779
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