Ultrafast, laser-scanning time-stretch microscopy with visible light

Wenwei Yan; Jianglai Wu; Kenneth K. Y. Wong; Kevin  K. Tsia

doi:10.1117/12.2251094

16 February 2017 Ultrafast, laser-scanning time-stretch microscopy with visible light

Wenwei Yan; Jianglai Wu; Kenneth K. Y. Wong; Kevin K. Tsia

Author Affiliations +

Proceedings Volume 10068, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV; 100681C (2017) https://doi.org/10.1117/12.2251094
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

We demonstrate ultrafast time-stretch microscopy in, to the best of our knowledge, the shortest wavelength regimes, i.e. 532 nm. This is enabled by a new all-optical ultrahigh-speed laser-scanning technique called free-space angular-chirpenhanced delay (FACED) that achieves a line-scan rate as high as 20 MHz. In contrast to the predominant fiber-based implementation, time-stretch imaging based on FACED allows wavelength-independent and low-loss operations, and more intriguingly reconfigurable all-optical laser-scanning rate. Using this technique, we present high-resolution single-cell images captured in an ultrafast microfluidic flow (1.5m/s). This could unleash numerous cell and tissue imaging applications, e.g. high-throughput image flow cytometry and whole-slide imaging.

Conference Presentation

Citation Download Citation

Wenwei Yan, Wenwei Yan, Jianglai Wu, Jianglai Wu, Kenneth K. Y. Wong, Kenneth K. Y. Wong, Kevin K. Tsia, Kevin K. Tsia, } "Ultrafast, laser-scanning time-stretch microscopy with visible light", Proc. SPIE 10068, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV, 100681C (16 February 2017); doi: 10.1117/12.2251094; https://doi.org/10.1117/12.2251094

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