Ten years of biophotonics single-photon SPAD imager applications: retrospective and outlook

Claudio Bruschini; Harald Homulle; Edoardo Charbon

doi:10.1117/12.2256247

21 February 2017 Ten years of biophotonics single-photon SPAD imager applications: retrospective and outlook

Claudio Bruschini, Harald Homulle, Edoardo Charbon

Proceedings Volume 10069, Multiphoton Microscopy in the Biomedical Sciences XVII; 100691S (2017) https://doi.org/10.1117/12.2256247
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

SPAD (single-photon avalanche diode) arrays are single-photon imagers that can provide unparalleled timeresolved sensing performance. Since their inception in standard CMOS technologies (2003), a host of architectures and target applications have been explored, ranging from simple pixel arrays, with off-chip data processing electronics, to fully integrated “smart” imagers with in-pixel time-stamping electronics and/or on-chip data processing fabric. Applications include (endoscopic) FLIM, (multi-beam multiphoton) FLIM-FRET, SPIMFCS, time-resolved Raman, NIROT, super-resolution microscopy, and PET, to name a few. We will review some representative sensors and applications, the corresponding challenges, and provide an outlook on the future of this fascinating technology

Conference Presentation

Citation Download Citation

Claudio Bruschini, Harald Homulle, and Edoardo Charbon "Ten years of biophotonics single-photon SPAD imager applications: retrospective and outlook", Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100691S (21 February 2017); https://doi.org/10.1117/12.2256247

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