2 March 2017 Multimodal optical imaging database from tumour brain human tissue: endogenous fluorescence from glioma, metastasis and control tissues
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Abstract
Eliminating time-consuming process of conventional biopsy is a practical improvement, as well as increasing the accuracy of tissue diagnoses and patient comfort. We addressed these needs by developing a multimodal nonlinear endomicroscope that allows real-time optical biopsies during surgical procedure. It will provide immediate information for diagnostic use without removal of tissue and will assist the choice of the optimal surgical strategy. This instrument will combine several means of contrast: non-linear fluorescence, second harmonic generation signal, reflectance, fluorescence lifetime and spectral analysis. Multimodality is crucial for reliable and comprehensive analysis of tissue. Parallel to the instrumental development, we currently improve our understanding of the endogeneous fluorescence signal with the different modalities that will be implemented in the stated. This endeavor will allow to create a database on the optical signature of the diseased and control brain tissues. This proceeding will present the preliminary results of this database on three types of tissues: cortex, metastasis and glioblastoma.
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Fanny Poulon, Fanny Poulon, Ali Ibrahim, Ali Ibrahim, Marc Zanello, Marc Zanello, Johan Pallud, Johan Pallud, Pascale Varlet, Pascale Varlet, Fatima Malouki, Fatima Malouki, Georges Abi Lahoud, Georges Abi Lahoud, Bertrand Devaux, Bertrand Devaux, Darine Abi Haidar, Darine Abi Haidar, } "Multimodal optical imaging database from tumour brain human tissue: endogenous fluorescence from glioma, metastasis and control tissues", Proc. SPIE 10069, Multiphoton Microscopy in the Biomedical Sciences XVII, 100692M (2 March 2017); doi: 10.1117/12.2249498; https://doi.org/10.1117/12.2249498
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