17 February 2017 Imaging beyond scattering limits utilizing ARF as a guidestar
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Optical imaging modalities are proved to be able to provide images with resolution required to image subcellular particles, however, imaging depth of optical imaging modalities are limited due to strong absorption and scattering. In contrast, ultrasound imaging modalities can provide images deeper in the tissue due to negligible scattering in tissue, but they suffer from poor resolution and contrast. Hybrid imaging modalities such as ultrasound modulated optical tomography (UOT) utilize advantages of both optical and ultrasound imaging modalities. UOT utilizes pressure waves to modulate light with ultrasound frequency that results in a week signal that requires expensive detection equipment. In Contrast, we propose to use acoustic radiation force (ARF) to tag the light that travels through the ultrasound focal spot and generate a stronger signal. Monitoring the changes in the speckle pattern reflects both mechanical and thermal properties of the medium. In this paper we have utilized our model with fixed-particle Monte Carlo to simulate the mean irradiance change (MIC) signal variations due to particle displacement and temperature rise. Results suggest that neglecting the temperature rise for short ultrasound exposure times, the change in the MIC signal reflects the local stiffness of the medium at the ultrasound focal spot and can be utilized to generate the stiffness image of the medium.
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Ali Vakili, Ali Vakili, Joseph L. Hollmann, Joseph L. Hollmann, R. Glynn Holt, R. Glynn Holt, Charles A. DiMarzio, Charles A. DiMarzio, } "Imaging beyond scattering limits utilizing ARF as a guidestar", Proc. SPIE 10070, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXIV, 100700W (17 February 2017); doi: 10.1117/12.2254758; https://doi.org/10.1117/12.2254758

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