17 February 2017 Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies
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Abstract
It is essential to monitor tissue perfusion during and after reconstructive surgery, as restricted blood flow can result in graft failures. Current clinical procedures are insufficient to monitor tissue perfusion, as they are intermittent and often subjective. To address this unmet clinical need, a compact, low-cost, multimodal diffuse correlation spectroscopy and diffuse reflectance spectroscopy system was developed. We verified system performance via tissue phantoms and experimental protocols for rigorous bench testing. Quantitative data analysis methods were employed and tested to enable the extraction of tissue perfusion parameters. This design verification study assures data integrity in future in vivo studies.
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Julia M. Pakela, Julia M. Pakela, Taylor L. Hedrick, Taylor L. Hedrick, Seung Yup Lee, Seung Yup Lee, Karthik Vishwanath, Karthik Vishwanath, Sara Zanfardino, Sara Zanfardino, Yooree G. Chung, Yooree G. Chung, Michael C. Helton, Michael C. Helton, Noah J. Kolodziejski, Noah J. Kolodziejski, Christopher J. Stapels, Christopher J. Stapels, Daniel R. McAdams, Daniel R. McAdams, Daniel E. Fernandez, Daniel E. Fernandez, James F. Christian, James F. Christian, Stephen E. Feinberg, Stephen E. Feinberg, Mary-Ann Mycek, Mary-Ann Mycek, } "Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies", Proc. SPIE 10072, Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics, 1007217 (17 February 2017); doi: 10.1117/12.2252811; https://doi.org/10.1117/12.2252811
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