21 February 2017 Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation
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Abstract
Optical phase conjugation (OPC) based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thicknesses used in wavefront shaping experiments have been limited to only a few millimeters or several transport mean free paths. Here, by using a long-coherence-length laser and an optimized digital OPC system that efficiently delivers light power, we focused 532 nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick.
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Yuecheng Shen, Yan Liu, Cheng Ma, Lihong V. Wang, "Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation", Proc. SPIE 10073, Adaptive Optics and Wavefront Control for Biological Systems III, 100730G (21 February 2017); doi: 10.1117/12.2251052; https://doi.org/10.1117/12.2251052
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