Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations

Ted A. Laurence; Sonny Ly; Erika Fong; Maxim Shusteff; Amanda Randles; John Gounley; Erik Draeger

doi:10.1117/12.2253319

22 February 2017 Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations

Ted A. Laurence, Sonny Ly, Erika Fong, Maxim Shusteff, Amanda Randles, John Gounley, Erik Draeger

Proceedings Volume 10076, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II; 100761E (2017) https://doi.org/10.1117/12.2253319
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The utility and accuracy of computational modeling often requires direct validation against experimental measurements. The work presented here is motivated by taking a combined experimental and computational approach to determine the ability of large-scale computational fluid dynamics (CFD) simulations to understand and predict the dynamics of circulating tumor cells in clinically relevant environments. We use stroboscopic light sheet fluorescence imaging to track the paths and measure the velocities of fluorescent microspheres throughout a human aorta model. Performed over complex physiologicallyrealistic 3D geometries, large data sets are acquired with microscopic resolution over macroscopic distances.

Citation Download Citation

Ted A. Laurence, Sonny Ly, Erika Fong, Maxim Shusteff, Amanda Randles, John Gounley, and Erik Draeger "Using stroboscopic flow imaging to validate large-scale computational fluid dynamics simulations", Proc. SPIE 10076, High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management II, 100761E (22 February 2017); https://doi.org/10.1117/12.2253319

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available