TiO2 nanoparticles for enhancing the refractive index of hydrogels for ophthalmological applications

Norbert Hampp; Christian Dams; Thorben Badur; Hendrik Reinhardt

doi:10.1117/12.2256296

22 February 2017 TiO₂ nanoparticles for enhancing the refractive index of hydrogels for ophthalmological applications

Norbert Hampp, Christian Dams, Thorben Badur, Hendrik Reinhardt

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Proceedings Volume 10078, Colloidal Nanoparticles for Biomedical Applications XII; 100780I (2017) https://doi.org/10.1117/12.2256296
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Intraocular lenses (IOL) are currently the only treatment for cataract dependent vision impairment and blindness [1]. A polymer suitable for IOL manufacture needs to meet a plurality of properties, biocompatibility, excellent transmission in the visible range, a high flexibility for micro invasive surgery, a high refractive index as well as a good ABBE-number, just to mention the most important ones [2]. We present the use of in situ generated TiO₂-nanoparticles to enhance the refractive index of poly-HEMA hydrogels - with are suitable polymers for IOL manufacture[3] – from 1.44 to 1.527 at 589.3 nm combined with an excellent ABBE-number of 54. The nanoparticles were prepared using titaniumdiisopropoxide- bis(acetylacetonate) as a precursor. First the titanium salt was diffused into the poly-HEMA matrix and then it was transformed into TiO₂ in boiling water. The resulting pHEMA [TiO₂] hydrogel was dried for 10 days under ambient conditions. By lathing these polymers were machined into lens precursors, the so-called Saturn-rings. After reswelling in physiological saline solutions flexible polymer lenses with high surface quality, shape memory and superior optical properties were obtained. The crystal structure of the formed TiO₂ nanoparticles was identified as anatase via Xray. No release of titanium ions or TiO₂ nanoparticles was observe under physiological conditions. Such hybrid materials of TiO₂ nanoparticles and poly-HEMA like hydrogels are promising materials for IOL.

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Norbert Hampp, Christian Dams, Thorben Badur, and Hendrik Reinhardt "TiO₂ nanoparticles for enhancing the refractive index of hydrogels for ophthalmological applications", Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 100780I (22 February 2017); https://doi.org/10.1117/12.2256296

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