22 February 2017 TiO2 nanoparticles for enhancing the refractive index of hydrogels for ophthalmological applications
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Intraocular lenses (IOL) are currently the only treatment for cataract dependent vision impairment and blindness [1]. A polymer suitable for IOL manufacture needs to meet a plurality of properties, biocompatibility, excellent transmission in the visible range, a high flexibility for micro invasive surgery, a high refractive index as well as a good ABBE-number, just to mention the most important ones [2]. We present the use of in situ generated TiO2-nanoparticles to enhance the refractive index of poly-HEMA hydrogels - with are suitable polymers for IOL manufacture[3] – from 1.44 to 1.527 at 589.3 nm combined with an excellent ABBE-number of 54. The nanoparticles were prepared using titaniumdiisopropoxide- bis(acetylacetonate) as a precursor. First the titanium salt was diffused into the poly-HEMA matrix and then it was transformed into TiO2 in boiling water. The resulting pHEMA [TiO2] hydrogel was dried for 10 days under ambient conditions. By lathing these polymers were machined into lens precursors, the so-called Saturn-rings. After reswelling in physiological saline solutions flexible polymer lenses with high surface quality, shape memory and superior optical properties were obtained. The crystal structure of the formed TiO2 nanoparticles was identified as anatase via Xray. No release of titanium ions or TiO2 nanoparticles was observe under physiological conditions. Such hybrid materials of TiO2 nanoparticles and poly-HEMA like hydrogels are promising materials for IOL.
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Norbert Hampp, Norbert Hampp, Christian Dams, Christian Dams, Thorben Badur, Thorben Badur, Hendrik Reinhardt, Hendrik Reinhardt, } "TiO2 nanoparticles for enhancing the refractive index of hydrogels for ophthalmological applications", Proc. SPIE 10078, Colloidal Nanoparticles for Biomedical Applications XII, 100780I (22 February 2017); doi: 10.1117/12.2256296; https://doi.org/10.1117/12.2256296

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