In powder materials scattering is also affected by particle size and the presence of cavities, which lead to a lack of precision and repeatability in Raman intensity measurements. We address this problem by spatial averaging using specific stage motion patterns. This design facilitates rapid and precise measurement of low-frequency vibrational modes, differentiation of polymorphs and other structural characteristics for applications in pharmaceuticals, nano- and bio-materials and for the characterization of industrial polymers where XRPD is commonly used.
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Anjan Roy, Jean-Charles Fosse, Filipe Fernandes, Alexandre Ringwald, Lawrence Ho, "Development of a high-throughput solution for crystallinity measurement using THz-Raman spectroscopy," Proc. SPIE 10110, Photonic Instrumentation Engineering IV, 101100O (20 February 2017);