24 February 2017 White matter fiber-based analysis of T1w/T2w ratio map
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Abstract
Purpose: To develop, test, evaluate and apply a novel tool for the white matter fiber-based analysis of T1w/T2w ratio maps quantifying myelin content. Background: The cerebral white matter in the human brain develops from a mostly non-myelinated state to a nearly fully mature white matter myelination within the first few years of life. High resolution T1w/T2w ratio maps are believed to be effective in quantitatively estimating myelin content on a voxel-wise basis. We propose the use of a fiber-tract-based analysis of such T1w/T2w ratio data, as it allows us to separate fiber bundles that a common regional analysis imprecisely groups together, and to associate effects to specific tracts rather than large, broad regions. Methods: We developed an intuitive, open source tool to facilitate such fiber-based studies of T1w/T2w ratio maps. Via its Graphical User Interface (GUI) the tool is accessible to non-technical users. The framework uses calibrated T1w/T2w ratio maps and a prior fiber atlas as an input to generate profiles of T1w/T2w values. The resulting fiber profiles are used in a statistical analysis that performs along-tract functional statistical analysis. We applied this approach to a preliminary study of early brain development in neonates. Results: We developed an open-source tool for the fiber based analysis of T1w/T2w ratio maps and tested it in a study of brain development.
Conference Presentation
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Haiwei Chen, Haiwei Chen, Francois Budin, Francois Budin, Jean Noel, Jean Noel, Juan Carlos Prieto, Juan Carlos Prieto, John Gilmore, John Gilmore, Jerod Rasmussen, Jerod Rasmussen, Pathik D. Wadhwa, Pathik D. Wadhwa, Sonja Entringer, Sonja Entringer, Claudia Buss, Claudia Buss, Martin Styner, Martin Styner, } "White matter fiber-based analysis of T1w/T2w ratio map", Proc. SPIE 10133, Medical Imaging 2017: Image Processing, 101330P (24 February 2017); doi: 10.1117/12.2254467; https://doi.org/10.1117/12.2254467
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