Automated liver elasticity calculation for 3D MRE

Bogdan Dzyubak; Kevin J. Glaser; Armando Manduca; Richard L. Ehman

doi:10.1117/12.2254476

3 March 2017 Automated liver elasticity calculation for 3D MRE

Bogdan Dzyubak, Kevin J. Glaser, Armando Manduca, Richard L. Ehman

Proceedings Volume 10134, Medical Imaging 2017: Computer-Aided Diagnosis; 101340Y (2017) https://doi.org/10.1117/12.2254476
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Magnetic Resonance Elastography (MRE) is a phase-contrast MRI technique which calculates quantitative stiffness images, called elastograms, by imaging the propagation of acoustic waves in tissues. It is used clinically to diagnose liver fibrosis. Automated analysis of MRE is difficult as the corresponding MRI magnitude images (which contain anatomical information) are affected by intensity inhomogeneity, motion artifact, and poor tissue- and edge-contrast. Additionally, areas with low wave amplitude must be excluded. An automated algorithm has already been successfully developed and validated for clinical 2D MRE. 3D MRE acquires substantially more data and, due to accelerated acquisition, has exacerbated image artifacts. Also, the current 3D MRE processing does not yield a confidence map to indicate MRE wave quality and guide ROI selection, as is the case in 2D. In this study, extension of the 2D automated method, with a simple wave-amplitude metric, was developed and validated against an expert reader in a set of 57 patient exams with both 2D and 3D MRE. The stiffness discrepancy with the expert for 3D MRE was -0.8% ± 9.45% and was better than discrepancy with the same reader for 2D MRE (-3.2% ± 10.43%), and better than the inter-reader discrepancy observed in previous studies. There were no automated processing failures in this dataset. Thus, the automated liver elasticity calculation (ALEC) algorithm is able to calculate stiffness from 3D MRE data with minimal bias and good precision, while enabling stiffness measurements to be fully reproducible and to be easily performed on the large 3D MRE datasets.

Conference Presentation

Citation Download Citation

Bogdan Dzyubak, Kevin J. Glaser, Armando Manduca, and Richard L. Ehman "Automated liver elasticity calculation for 3D MRE", Proc. SPIE 10134, Medical Imaging 2017: Computer-Aided Diagnosis, 101340Y (3 March 2017); https://doi.org/10.1117/12.2254476

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available