A feasibility study on estimation of tissue mixture contributions in 3D arterial spin labeling sequence

Yang Liu; Huangsheng Pu; Xi Zhang; Baojuan Li; Zhengrong Liang; Hongbing Lu

doi:10.1117/12.2254067

13 March 2017 A feasibility study on estimation of tissue mixture contributions in 3D arterial spin labeling sequence

Yang Liu, Huangsheng Pu, Xi Zhang, Baojuan Li, Zhengrong Liang, Hongbing Lu

Proceedings Volume 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging; 1013721 (2017) https://doi.org/10.1117/12.2254067
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Arterial spin labeling (ASL) provides a noninvasive measurement of cerebral blood flow (CBF). Due to relatively low spatial resolution, the accuracy of CBF measurement is affected by the partial volume (PV) effect. To obtain accurate CBF estimation, the contribution of each tissue type in the mixture is desirable. In general, this can be obtained according to the registration of ASL and structural image in current ASL studies. This approach can obtain probability of each tissue type inside each voxel, but it also introduces error, which include error of registration algorithm and imaging itself error in scanning of ASL and structural image. Therefore, estimation of mixture percentage directly from ASL data is greatly needed. Under the assumption that ASL signal followed the Gaussian distribution and each tissue type is independent, a maximum a posteriori expectation-maximization (MAP-EM) approach was formulated to estimate the contribution of each tissue type to the observed perfusion signal at each voxel. Considering the sensitivity of MAP-EM to the initialization, an approximately accurate initialization was obtain using 3D Fuzzy c-means method. Our preliminary results demonstrated that the GM and WM pattern across the perfusion image can be sufficiently visualized by the voxel-wise tissue mixtures, which may be promising for the diagnosis of various brain diseases.

Citation Download Citation

Yang Liu, Huangsheng Pu, Xi Zhang, Baojuan Li, Zhengrong Liang, and Hongbing Lu "A feasibility study on estimation of tissue mixture contributions in 3D arterial spin labeling sequence", Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1013721 (13 March 2017); https://doi.org/10.1117/12.2254067

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