13 March 2017 Early classification of Alzheimer's disease using hippocampal texture from structural MRI
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Convergent evidence has been collected to support that Alzheimer’s disease (AD) is associated with reduction in hippocampal volume based on anatomical magnetic resonance imaging (MRI) and impaired functional connectivity based on functional MRI. Radiomics texture analysis has been previously successfully used to identify MRI biomarkers of several diseases, including AD, mild cognitive impairment and multiple sclerosis. In this study, our goal was to determine if MRI hippocampal textures, including the intensity, shape, texture and wavelet features, could be served as an MRI biomarker of AD. For this purpose, the texture marker was trained and evaluated from MRI data of 48 AD and 39 normal samples. The result highlights the presence of hippocampal texture abnormalities in AD, and the possibility that texture may serve as a neuroimaging biomarker for AD.
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Kun Zhao, Kun Zhao, Yanhui Ding, Yanhui Ding, Pan Wang, Pan Wang, Xuejiao Dou, Xuejiao Dou, Bo Zhou, Bo Zhou, Hongxiang Yao, Hongxiang Yao, Ningyu An, Ningyu An, Yongxin Zhang, Yongxin Zhang, Xi Zhang, Xi Zhang, Yong Liu, Yong Liu, } "Early classification of Alzheimer's disease using hippocampal texture from structural MRI", Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, 101372E (13 March 2017); doi: 10.1117/12.2254198; https://doi.org/10.1117/12.2254198

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